Integrins in angiogenesis and lymphangiogenesis
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چکیده
منابع مشابه
Angiogenesis and Lymphangiogenesis in Bladder Cancer
In cancer patients, the majority of deaths occur as a consequence of metastatic diseases. In addition, metastasis is a marker for poor prognosis and low quality of life in many malignancies. Several groups have investigated the mechanism of tumor metastasis. Metastatic lesions are formed through a multi-step complex process and then spread either locally at the site of the primary tumor, or int...
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Blood and lymphatic vessels develop in a parallel, but independent manner, and together form the circulatory system allowing the passage of fluid and delivering molecules within the body. Although the lymphatic vessels were discovered 300 years ago, at the same time as the blood circulation was described, the lymphatic system has remained relatively neglected until the present. This is in part ...
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The pathogenesis of abdominal aortic aneurysm (AAA) is characterized to be inflammation-associated degeneration of vascular wall. Neovascularization is regularly found in human AAA and considered to play critical roles in the development and rupture of AAA. However, little is known about lymphangiogenesis in AAA. The purpose of this study was to demonstrate both angiogenesis and lymphangiogenes...
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During angiogenesis, av integrins are overexpressed on the endothelial cell surface to facilitate the growth and survival of newly forming vessels. Accordingly, blockingav integrin function by disrupting ligand binding can produce an antiangiogenic effect. Although the integrin ectodomain regulates ligand binding specificity, the short cytoplasmic tail facilitates intracellular signaling pathwa...
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ژورنال
عنوان ژورنال: Nature Reviews Cancer
سال: 2008
ISSN: 1474-175X,1474-1768
DOI: 10.1038/nrc2353